[D-Asp3]-Microcystin-LR_product_DataBase

Bioactivity	Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. Microcystin-[D-Asp3]-LR/Microcystin A can activate Nrf2 and promote oxidative stress response. Microcystin-[D-Asp3]-LR/Microcystin A can also be used in toxicology research[1][2].
Invitro	Microcystin 的毒性主要靶向肠、肝、肾和生殖系统。其分子毒理学涉及蛋白磷酸酶的共价结合和抑制、氧化应激、细胞死亡（自噬、凋亡、坏死）和细胞骨架破坏[1]。Microcystin-[D-Asp3]-LR/Microcystin A ([D-Asp3]-LR Microcystin) (1 μM) 显着增加 Nrf2 活性，从而表明氧化应激反应诱导[2]。
Name	[D-Asp3]-Microcystin-LR
CAS	120011-66-7
Formula	C48H72N10O12
Molar Mass	981.15
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Arman T, et al. Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans. Toxins (Basel). 2021 Jul 29;13(8):537. [2]. Lundqvist J, et al. Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins. Toxicon. 2017 Feb;126:47-50.

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